Lewy bodies play a central role in a range of neurodegenerative conditions — including Parkinson’s disease, dementia and Lewy Body Dementia (LBD) — and understanding them is key to supporting loved ones affected by these complex illnesses. The American Parkinson Disease Association (APDA) provides an excellent overview of how Lewy bodies, formed from misfolded alpha-synuclein proteins, disrupt brain function and contribute to both movement and cognitive symptoms.
At Dolan Memory Care, we build on this foundation with specialized expertise in LBD to help families recognize symptoms, understand causes, and find support along the caregiving journey.
What Are Lewy Bodies — and Why Do They Matter?
Lewy bodies are abnormal clumps of the protein alpha-synuclein that accumulate in neurons and interfere with normal cell communication. These protein aggregates can appear in different regions of the brain — from the brainstem, which affects movement and automatic functions, to the cerebral cortex, which governs thinking and memory. Their location helps explain why symptoms can span cognitive, motor, and behavioral domains.
This overlapping symptom profile is why conditions like Parkinson’s Disease, Dementia and Dementia with Lewy Bodies (DLB) often appear similar and can be difficult to differentiate. APDA highlights that care partners may experience confusion over terminology and diagnosis, which is why a clear, supportive care strategy is so important.
Causes & Risk Factors: A Closer Look
While researchers are still uncovering the precise triggers of alpha-synuclein misfolding, Dolan Memory Care shares that abnormal protein accumulation is the underlying biological cause of LBD. These misfolded proteins disrupt neurons in critical areas responsible for memory, movement, mood, and sleep — explaining why individuals with LBD may experience:
- Fluctuating cognition and attention
- Visual hallucinations
- Parkinsonian motor symptoms (e.g., stiffness or gait difficulties)
- Sleep disturbances and REM behavior changes
Although age remains the strongest risk factor — with risk increasing after age 60 — genetics and environmental exposures may also play a role in who develops LBD.
You can learn more about the causes of Lewy Body Dementia in detail at Dolan Memory Care’s insights page:
👉 Understanding the causes of LBD: https://dolancare.com/what-causes-lewy-body-dementia-insights-from-dolan-memory-care/
Recognizing Symptoms & Seeking Accurate Diagnosis
APDA emphasizes that distinguishing between types of Lewy body-related conditions can be challenging because many symptoms overlap with other dementias or Parkinson’s disease itself. This makes early recognition and tailored evaluation critical for planning effective care.
At Dolan Memory Care, we focus on educating families about the unique symptom patterns of LBD — including cognitive fluctuations, hallucinations, and movement changes — to help reduce misdiagnosis and support clearer communication with healthcare providers.
To explore these symptoms more fully and discover supportive strategies, visit our guide on Understanding Lewy Body Dementia and the support available to families:
👉 https://dolancare.com/understanding-lewy-body-dementia-and-finding-support-along-the-way/
Supporting Families & Care Partners
Living with LBD affects not only the individual but also entire families. Dolan Memory Care recognizes the emotional, physical, and logistical challenges caregivers face. That’s why we offer:
- Educational resources about symptoms and causes
- Monthly in-person support groups for care partners
- Memory care environments designed specifically for individuals with Lewy Body Dementia
Care partners can find understanding, practical tips, and community with others walking similar paths — because no one should navigate dementia care alone.
Final Thoughts
Lewy bodies are at the heart of some of the most complex neurodegenerative conditions, and learning about them empowers families to advocate for the best possible care. With insights from APDA on the biology of Lewy body disorders and Dolan Memory Care’s compassionate, specialized support, you can better recognize symptoms, understand causes, and connect with resources that make a difference every day.
For families looking for guidance and community, Dolan Memory Care is here to support you every step of the way.
